Emmy-winning American actress Mary Tyler Moore died at age 80, according to the spokeswoman.
He is best known for his television role in the 1960 comedy, Dick Van Dyke Show and The Mary Tyler Moore Show of the same name in 1970.
He was also nominated for an Oscar for Best Actress in 1980 in the movie Ordinary People.
Mara Buxbaum said in a statement that he died in the company of friends and her husband, Mr. S. Robert Levine.
He had suffered from diabetes since the 1930’s and is a brain surgery in 2011.
Born in Brooklyn, New York, Moore moved to Los Angeles when she was eight years old and began her career in the entertainment world as a 17-year-old dancer.
His first appearance was in 1950 ad Hotpoint, duende dress.
But parts of her grew in size during that decade before she landed the role of wife Laura Petrie of The Dick Van Dyke Show in 1961.
He then delivered a TV producer Mary Richards in his self-titled comedy. Running seven years from 1970 to 1977, he was named by Time magazine as one of 17 countries that have “television changed.”
Moore appeared on the screen at the same time when the role of women is the main characters of the traditional housewife.
But modern pants and Jackie Kennedy-style hair, and playing a woman, who lived alone and career, he challenged stereotypes in front of millions of viewers.
Moore created her then-husband Grant Tinker and produce the show and some ancillary activities as well as other hit shows such as Hill Street Blues, St. Elsewhere, and Remington Steele.
TV presenter Oprah Winfrey Moore described as one of the initial inspiration, he watched the show every week as a child.
“I want her,” he said. “I want to live where she lives.”
Actor Stephen Fry, read in Hollywood popularized by Moore Show tweets: “One minute of silence we remember one of the real big names in comedy TV.”
Director Kevin Smith praised the work of his campaign by tweeting: “TV [and] a movie star, tireless defender of animals, and the scourge of true diabetes, he turned to the world with a smile ..”
And Matt Sharp, one of the founding members of the rock band Weezer, referred to the actor beating Buddy Holly, tweeted, “I never met him, but Mary Tyler Moore delivered to each of us … signed pic on top Buddy. It’s sweet because it’s real. “